幹細胞ã®æ­´å²

  Edited by AllStemCells.com
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幹細胞ã®æ­´å²(ã‹ã‚“ã•ã„ã¼ã†ã®ã‚Œãã—) : History of Stem Cell

â– 1908年:幹細胞ã¨ã„ã†ç”¨èªžã¯ã€ãƒ™ãƒ«ãƒªãƒ³è¡€æ¶²å­¦ä¼šã§ãƒ­ã‚·ã‚¢ã®çµ„織学者ã§ã‚る「アレキサンダー膜下(Alexander Maksimovã€1874-1928)ã€ã«ã‚ˆã£ã¦ç§‘学的使用を目的ã¨ã—ã¦é–‹å§‹ã•ã‚ŒãŸã€‚ã“ã‚Œã¯é€ è¡€æŸå¹¹ç´°èƒžã®ä»®æƒ³çš„ãªå­˜åœ¨ã§ã‚ã£ãŸã€‚
â– 1968年:二人ã®å§‰å¦¹ã®é–“ã®éª¨é«„移æ¤ã®æœ€åˆæ–½è¡Œã€‚
â– 1978年:人間ã®è‡å¸¯è¡€ã‹ã‚‰é€ è¡€æŸå¹¹ç´°èƒžã‚’発見ã—ãŸã€‚
â– 1981年:ラットã®èƒšæ€§å¹¹ç´°èƒžãŒã€ç§‘学者マーティンエヴァンã¨ã‚²ã‚¤ãƒ«R.マーティンã«ã‚ˆã£ã¦å†…部細胞ã‹ã‚‰èª˜å°Žã•ã‚ŒãŸã€‚ゲイルマーティンã¯ã€ã“れを「胚性幹細胞ã€ã¨ã„ã†ç”¨èªžã‚’最åˆã«ä½œæˆã—ãŸã€‚
â– 1996年:クローン羊ドリーã®æˆåŠŸ
â– 1997年:白血病ãŒé€ è¡€æŸå¹¹ç´°èƒžã‹ã‚‰é–‹å§‹ã•ã‚Œã€ç™Œã®å¹¹ç´°èƒžã®æœ€åˆã®è¨¼æ˜ŽãŒã•ã‚ŒãŸã€‚
â– 1998年:ウィスコンシン – マディソン大学ã§ã‚¸ã‚§ã‚¤ãƒ ã‚½ãƒ³ãƒˆãƒ³ãƒ—ソンã¨ä»²é–“ãŸã¡ãŒæœ€åˆèƒšæ€§å¹¹ç´°èƒžã‚’誘導ã—ãŸã€‚
â– 2004年:韓国ã®ç ”究者ã€é»„禹錫åšå£«ã®äººé–“ã®åµå­ã§è¤‡æ•°èƒšæ€§å¹¹ç´°èƒžæ ªã‚’作ã£ãŸã¨ã„ã†ä¸»å¼µã¨ç™ºè¡¨ã«ã¤ã„ã¦è­°è«–ã¨å•é¡ŒãŒã‚ã£ãŸã€‚
â– 2006年:「Cellã€ã¨ã„ã†é›‘誌ã§çœŸä¹Ÿå±±ä¸­åšå£«ã¨å‹ä¿Šé«˜æ©‹åšå£«ã«ã‚ˆã£ã¦ã€Œãƒ©ãƒƒãƒˆã®å¤šèƒ½æ€§å¹¹ç´°èƒžã®èª˜å°Žã€ãŒç™ºè¡¨ã•ã‚ŒãŸã€‚
â– 2006年:英国ニューカッスル大学ã®ç§‘学者ãŸã¡ãŒè‡å¸¯è¡€ã®å¹¹ç´°èƒžã‚’使用ã—ã¦æœ€åˆã®å¹¹ç´°èƒžã‚’作ã£ãŸã€‚
â– 2007年:ãƒãƒ¼ãƒãƒ¼ãƒ‰å¤§å­¦ã¨ã‚¢ãƒ³ã‚½ãƒ‹ãƒ¼ã‚¢ãƒ«ã‚¿ãƒ©åšå£«ã®ä¸»å°Žã®ä¸‹ã«ã‚¦ã‚§ã‚¤ã‚¯ãƒ•ã‚©ãƒ¬ã‚¹ãƒˆå¤§å­¦ã®ç§‘学者ãŸã¡ãŒæ­£ã§ã®æ–°ã—ã„タイプã®å¹¹ç´°èƒžã®ç™ºè¦‹ã‚’発表ã—ãŸã€‚ã“ã‚Œã«ã‚ˆã‚Šã€èƒšæ€§å¹¹ç´°èƒžã®ç ”究ã¨æ²»ç™‚的使用ã®ãŸã‚ã®é¸æŠžè‚¢ã‚’æä¾›ã™ã‚‹ã“ã¨ãŒã§ãるよã†ã«ãªã£ãŸã€‚
â– 2012年:山中伸弥ã¨John GurdonãŒã€Œæˆç†Ÿã—特化ã•ã‚ŒãŸç´°èƒžãŒäººä½“ã®ç´°èƒžçµ„ç¹”ã§è‚²ã¤ã“ã¨ãŒã§ãる未æˆç†Ÿç´°èƒžã«å†ãƒ—ログラムã™ã‚‹ã“ã¨ãŒã§ãã‚‹ã“ã¨ã‚’発見ã—(iPS)ã€ã—ãŸåŠŸåŠ´ã§ãƒŽãƒ¼ãƒ™ãƒ«ç”Ÿç†å­¦â€¢åŒ»å­¦è³žã‚’å—賞ã—ãŸã€‚

 

幹細胞ã®ã‚¿ã‚¤ãƒ ãƒ©ã‚¤ãƒ³

ソース:http://gladstoneinstitutes.org

stem_cell_timeline
1.Gurdon, JB, Elsdale TR, Fischberg M. Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 182: 65–65. 1958.
2.Till J, McCulloch E. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiation Research 14 (2): 213–222, 1961.
3.Jaenisch R, Mintz B. Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc. Natl. Acad. Sci. USA 71(4): 1250–1254, 1974.
4.Evans M, Kaufman M. Establishment in culture of pluripotential cells from mouse embryos. Nature 292 (5819): 154–156, 1981.
5.Martin G. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78 (12): 7634–7638, 1981.
6.Campbell KHS, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 380 (6569): 64–66, 1996.
7.Jones J, Marshall V, Swiergiel J, Waknitz M, Shapiro S, Itskovits-Eldor J, Thomson J. Embryonic stem cell lines derived from human blastocysts. Science 282 (5391): 1145–1147, 1998.
8.Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663–676, 2006.
9.Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861–872, 2007.
10.Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 26: 2008, Epub 2007 Nov 30.
11.Yu J, Vodyanik M, Smuga-Otto K, Antosiewicz-Bourget J, Frane J, Tian S, Nie J, Jonsdottir G, Ruotti V, Stewart R, Slukvin I, Thomson J. Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920, 2007. Epub Nov 2007.
12.Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady CP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318(5858): 1920-1923, 2007.
13.Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of Parkinson’s disease. Proc. Natl. Acad. Sci. USA 105(15): 5856-5861, 2008.
14.Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 322 (5903): 949-953, 2008.
15.Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463 (7284): 1035-41. Epub 2010 Jan 27.
16.Ieda M, Fu J, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau B, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142: 375-386, 2010.
17.Szabo E, Rampalli S, Risueno R, Schnerch A, Mitchell R, Fiebig-Comyn A, Levadoux-Martin M, Bhatia M. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468: 521-526, 2010.
18.Zhu S, Li W, Zhou H, Wei W, Ambasudhan R, Lin T, Kim J, Zhang K, Ding S. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 7:651–655, 2010.
19.Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton S, Ding S. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 9: 113-118, 2011.
20.Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 485: 593–8, 2012.
21.The HD iPSC Consortium. Induced Pluripotent Stem Cells from Patients with Huntington’s Disease Show CAG-Repeat-Expansion-Associated Phenotypes. Cell Stem Cell 11:264-278, 2012.
22.http://mainichi.jp/english/english/newsselect/news/20120613p2a00m0na005000c.html
23.Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 11: 100-9, 2012.
24.Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S. Derivation conditions impact x-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell 11: 91-9, 2012.

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