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์•ฝ์‚ฐ์„ฑ์—์„œ ์ฒด์„ธํฌ๊ฐ€ ๋งŒ๋Šฅ์„ธํฌ๋กœ ๋ถ„ํ™”๊ฐ€๋Šฅ?

— 2015-07-10

Haruko-Obokata

2014๋…„ ์ด์Šˆํ™”๋œ ์ค„๊ธฐ์„ธํฌ ๋…ผ๋ฌธ์กฐ์ž‘ ์ด์•ผ๊ธฐ

์•ฝ์‚ฐ์„ฑ์—์„œ ์ฒด์„ธํฌ๊ฐ€ ๋งŒ๋Šฅ์„ธํฌ๋กœ ๋ถ„ํ™”๊ฐ€๋Šฅ?

Haruko-Obokata2

2014๋…„ 1์›” ์ค„๊ธฐ์„ธํฌ, ์ƒ๋ช…๊ณตํ•™ ๊ด€๊ณ„์ž๋“ค์—๊ฒŒ ์ด์Šˆ๊ฐ€ ๋˜์—ˆ๋˜ ์‚ฌ๊ฑด์ด ์žˆ์—ˆ๋‹ค. ์ด๋Š” iPS๋กœ ๋…ธ๋ฒจ์ƒ์„ ๋ฐ›์€ ์ผ๋ณธ์ด๋ผ๋Š” ๊ตญ๊ฐ€์—์„œ ์ผ์–ด๋‚œ ์ผ์ด๋ผ, ๋”๋”์šฑ ์„ธ๊ฐ„์˜ ๊ด€์‹ฌ์ด ๋†’์•˜๋‹ค.
๋Œ€๋ถ€๋ถ„์˜ ๊ด€๊ณ„์ž๋“ค์€ ๊ทธ ๋ฐœํ‘œ๊ฐ€ ์‚ฌ์‹ค์ด๋ผ๋ฉด ์ง€๊ธˆ๊นŒ์ง€ ๊ณผํ•™์ž๋“ค์˜ ๋…ธ๋ ฅ์ด ํ—›์ˆ˜๊ณ ๊ฐ€ ์•„๋‹ˆ์—ˆ๋‚˜, ์•„๋งˆ๋„ ๊ทธ๊ฒƒ์ด ์‚ฌ์‹ค์ด๋ผ๊ณ  ํ•ด๋„ ์•„์ฃผ ์šฐ์—ฐํ•˜๊ฒŒ ๋‚˜ํƒ€๋‚œ ๊ฒƒ์„ ์ˆ˜์ฐจ๋ก€ ๋ฐ˜๋ณต์—ฐ๊ตฌ๊ฐ€ ๋” ์žˆ์—ˆ์–ด์•ผ ํ•˜๋Š”๋ฐ ์„ฑ๊ธ‰ํ•œ ๋ฐœํ‘œ๋ผ๋Š” ์˜๊ฒฌ๋“ค์ด ์žˆ์—ˆ๋‹ค.
๊ทธ ๊ฒฐ๊ณผ๋Š” ์‚ฌ์‹ค์ด ์•„๋‹ˆ์—ˆ๋‹ค.2014๋…„ 1์›” 30์ผ ๋„ค์ด์ฒ˜(NATURE)่ชŒ์— ๋ฐœํ‘œ๋œ โ€˜Stimulus-triggered fate conversion of somatic cells into pluripotencyโ€™ ๋ผ๋Š” ์ฃผ์ œ์˜ ๋…ผ๋ฌธ์ด์—ˆ๋‹ค. ์ด๋Š” ์ƒˆ๋กœ์šด ๋ฐฉ์‹์œผ๋กœ์˜ ๋งŒ๋Šฅ์„ธํฌ๋ฅผ ๋ฐœ๊ฒฌํ–ˆ๋‹ค๋Š” ๋‚ด์šฉ์˜ ๋…ผ๋ฌธ์œผ๋กœ ์ผ๋ณธ ์ดํ™”ํ•™์—ฐ๊ตฌ์†Œ์˜ ์˜ค๋ณด์นดํƒ€ ํ•˜๋ฃจ์ฝ”(Haruko Obokata, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Womenโ€™s Hospital)๊ฐ€ ๋ฐœํ‘œ๋ฅผ ํ–ˆ๋‹ค. ๊ทธ๋…€๋Š” ์ฒด์„ธํฌ๋ฅผ ์•ฝ์‚ฐ์„ฑ ์šฉ์•ก์— ๋‹ด๊ทธ๋ฉด ์‹ ์ฒด์˜ ์–ด๋–ค ์„ธํฌ๋กœ๋„ ๋ณ€ํ•  ์ˆ˜ ์žˆ๋Š” ๋งŒ๋Šฅ์„ธํฌ๊ฐ€ ๋  ์ˆ˜ ์žˆ๋‹ค๋Š” ๋‚ด์šฉ์œผ๋กœ ๋…ผ๋ฌธ์„ ๋ฐœํ‘œํ•˜์˜€๋‹ค.
๊ธฐ์กด์˜ ์—ญ๋ถ„ํ™”์ค„๊ธฐ์„ธํฌ ์—ฐ๊ตฌ๋ฐฉ์‹๊ณผ ๋‹ฌ๋ฆฌ ๊ทธ ์–ด๋–ค ์œ ์ „์ž ์กฐ์ž‘๋„ ํ•„์š”์—†์ด ๋‹จ์ˆœํžˆ ์•ก์ฒด์— ๋‹ด๊ทธ์—ˆ๋‹ค๋Š” ์ด์œ ๋กœ ์ค„๊ธฐ์„ธํฌ๋ฅผ ๋งŒ๋“ค ์ˆ˜ ์žˆ๋‹ค๋Š” ๊ธฐ์‚ฌ๋Š” ๋งค์šฐ ํš๊ธฐ์ ์ด์—ˆ๋‹ค. ๊ธฐ์กด์˜ ํ•ต์‹ฌ์—ฐ๊ตฌ๊ฒฐ๊ณผ ๋ฐœํ‘œ์ž๋“ค์™€ ๋‹ฌ๋ฆฌ ์ Š์€ ์—ฐ๊ตฌ์ฃผ์ž„์ด ๋ฐœํ‘œ๋ฅผ ํ–ˆ๋‹ค๋Š” ๋ฐ์— ์งง์€ ์‹œ๊ฐ„์ด์—ˆ์ง€๋งŒ ๊ณผํ•™๊ณ„์—์„œ ๋†€๋ผ์›€์„ ๊ฐ์ถ”์ง€ ๋ชปํ–ˆ๋‹ค.
์˜ค๋ Œ์ง€์ฃผ์Šค์— ์ฒด์„ธํฌ๋ฅผ ๋„ฃ์—ˆ๋”๋‹ˆ ๋งŒ๋Šฅ์ค„๊ธฐ์„ธํฌ๊ฐ€ ๋œ๋‹ค?

Haruko-Obokata3

๋…ผ๋ฌธ๋ฐœํ‘œ ํ›„ ์ค„๊ธฐ์„ธํฌ ์—ฐ๊ตฌ์ž๋“ค์€ ๋น„๊ณต์‹์ ์ธ ์ž๋ฆฌ์—์„œ ๋งŽ์€ ์˜๋ฌธ์„ ๋‚ด๋†“์•˜๋‹ค. ์šฐ์—ฐํžˆ ์ฃผ์Šค์— ๋„ฃ์—ˆ๋‹ค๊ณ ? ์˜ค๋ Œ์ง€์ฃผ์Šค, ๋ ˆ๋ชฌ์ฃผ์Šค? ๋ง์ด ๋˜๋Š”๊ฐ€? ์šฐ์—ฐํžˆ ๋‚˜ํƒ€๋‚œ ๋น„์ •์ƒ์ ์ธ ์ผ์ด ์•„๋‹Œ๊ฐ€? ์•ฝ์‚ฐ์„ฑ์˜ ์ •๋„๊ฐ€ ์–ผ๋งˆ์ธ๊ฐ€? ๋“ฑ์— ๋Œ€ํ•ด ์˜๊ฒฌ์ด ์ฐธ ๋ถ„๋ถ„ํ–ˆ๋‹ค. ์ง€๋‚˜๊ณ  ๋ณด๋ฉด ์ฐธ ๊ทธ ์ฃผ์ œ๋กœ ๋…ผ์Ÿ์ด ์žˆ์—ˆ๋‹ค๋Š” ๊ฒƒ์— ์›ƒ์Œ์ง“๊ฒŒ ํ•˜๋Š” ์‚ฌ๊ฑด์ด์—ˆ๋‹ค.
๊ทธ ๋…ผ๋ฌธ ๋‚ด์šฉ์ด ์„ธํฌ ๋ถ„ํ™”์™€ ์‹คํ—˜ ๋“ฑ์ด ๋‹จ๊ณ„์ ์œผ๋กœ ๋งค์šฐ ์ƒ์„ธํ•˜๊ฒŒ ํ’€์–ด๋‚ด์—ˆ๋‹ค. ๋‚ฎ์€ ์•ฝ์‚ฐ์„ฑ์ด ์ฒด์„ธํฌ ์šด๋ช…์„ ๋ณ€ํ™˜์‹œํ‚ค๋Š” ๋ฐฉ์•„์‡ ์—ญ์„ ํ•œ๋‹ค๋ผ๋Š” ๋‚ด์šฉ(Low pH triggers fate conversion in somatic cells), ์‹ฌ์ง€์–ด ์ž๊ทน์— ์˜ํ•œ ํš๋“๋œ ๋งŒ๋Šฅ์„ธํฌ(stimulus-triggered acquisition of pluripotency (STAP) Cell)์ด ํ‚ค๋ฉ”๋ผ๋งˆ์šฐ์Šค์„ธํฌ๋กœ ๋ถ„ํ™”๊ฐ€ ๊ฐ€๋Šฅํ•˜๊ณ  ์ค„๊ธฐ์„ธํฌ์ฒ˜๋Ÿผ ๋ฐฐ์•„์ค„๊ธฐ์„ธํฌ๋กœ ๋ถ„ํ™”๋  ์ˆ˜๋„ ์žˆ๋‹ค๋Š” ๋‚ด์šฉ(Chimaeric mouse generation from STAP cell, ES-cell-like stem cells can be derived from STAP cells) ์„ ๋ณด๋ฉด ์„ค๋งˆ ๊ฑฐ์ง“ ์—ฐ๊ตฌ๋ฅผ ์ด๋ ‡๊ฒŒ ํ’€์–ด ๋ฐœํ‘œ๊นŒ์ง€ ํ–ˆ์„๊นŒ ๋“ฑ์˜ ์˜๋ฌธ์„ ๋ฐ›์œผ๋ฉฐ ์ง„์‹ค๊ณผ ๊ฑฐ์ง“ ์‚ฌ์ด์—์„œ ์˜๊ฒฌ์ด ๋ถ„๋ถ„ํ–ˆ์ง€๋งŒ, ๊ฒฐ๊ณผ์ ์œผ๋กœ ์ง„์‹ค์ด ์•„๋‹ˆ๋ผ๋Š” ํŒ๋ช…์„ ๋ฐ›์•˜๋‹ค. ๊ทธ๋…€๊ฐ€ ๊ณผ๊ฑฐ์—๋„ ๋…ผ๋ฌธ์„ ์กฐ์ž‘ํ•œ ๊ฒฝ๋ ฅ์ด ์žˆ๋‹ค๋Š” ์ต๋ช…์˜ ์ œ๋ณด๋กœ ์ธํ•ด, ์ „์„ธ๊ณ„์˜ ๊ฒ€์ฆ์—ฐ๊ตฌํŒ€์ด ๋…ผ๋ฌธ์„ ๊ฒ€์ฆํ–ˆ์œผ๋‚˜, ๋ชจ๋“  ๊ฒ€์ฆ์ด ์‹คํŒจํ–ˆ๋‹ค๋Š” ์‚ฌ์‹ค์ด ๋„ค์ด์ฒ˜์ง€์— ๊ฒŒ์žฌ๋จ์œผ๋กœ์จ, 2014๋…„ 7์›” ์ผ๋ณธ์€ ๋…ผ๋ฌธ์„ ๊ณต์‹์ ์œผ๋กœ ์ฒ ํšŒํ•˜๊ณ  (Retraction: Stimulus-triggered fate conversion of somatic cells into pluripotency) ๋ฐœํ‘œ์ž ์‚ฌ๊ณผ๋ฐœํ‘œ๋กœ ๋งˆ๋ฌด๋ฆฌ๋ฅผ ํ•˜์˜€๋‹ค.
2014 (c) Edited by All Stem Cells Korea
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