Differentiation potential of ADSC into neuron cells
— 2015-05-26
According to this study; Transdifferentiation potential of adipose-derived stem cells into neural lineage and their application(2014), it shows the capability that ADSCs can differentiate into neuron cells.
Adipose-derived stem cells are a kind of mesenchymal stem cells which have a higher frequency in the adipose tissue and can be harvested by minimally invasive procedures. These cells are able to differentiate into other cells outside their lineage such as neuron, neurotrophic factor secreting cells and Schwann cells.
Many of the identified neurotrophic factors such as brain-derived neurotrophic factor, nerve growth factor, and glial cell line-derived neurotrophic factor can be produced by adipose-derived stem cells. In addition, these cells when differentiated into neurotrophic factor secreting cells are able to secrete a significantly high level of these factors. Neurotrophic factors have a significant role in cellular processes include cell proliferation, differentiation and maturation. This article reviews the in vitro differentiation of adiposederived stem cells into neural lineage cells and clinical application.
Many of the identified neurotrophic factors such as brain-derived neurotrophic factor, nerve growth factor, and glial cell line-derived neurotrophic factor can be produced by adipose-derived stem cells. In addition, these cells when differentiated into neurotrophic factor secreting cells are able to secrete a significantly high level of these factors. Neurotrophic factors have a significant role in cellular processes include cell proliferation, differentiation and maturation. This article reviews the in vitro differentiation of adiposederived stem cells into neural lineage cells and clinical application.
Figure 1. Transdifferentiation potential of adipose-derived stem cells into neural lineage cells. Phase contrast image of human adipose-derived stem cells (A), Neuron cells (B), Schwann cells (C), neurotrophic factor (NTF)-secreting cells following differentiation (D); Scale bar: A=100 μm, B, C,D=150 μm.
ADSCs are a promising cell source for neural regenerative due to their ability to differentiate into neural lineages cells, and ability to secrete various neurotrophic factors. A large number of clinical examinations using ADSCs have already performed and many of them showed ADSCs are effective on neural tissue regeneration.
Source : Ghasemi et al. Journal of Histology & Histopathology 2014,
http://www.hoajonline.com/journals/pdf/2055-091X-1-12.pdf
http://www.hoajonline.com/journals/pdf/2055-091X-1-12.pdf
Keywords: Adipose-derived stem cells, neurogenic differentiation, schwann cells, neurotrophic factor, secreting cells
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