SENSITIVITY OF NATURAL KILLER CELLS TO ACTIVATION IN THE PROCESS OF AGEING
— 2015-05-07This report show the correlation of Natural Killer Cells Activity and aging.
Source :Â SENSITIVITY OF NATURAL KILLER CELLS TO ACTIVATION IN THE PROCESSÂ OF AGEING IS RELATED TO THE OXIDATIVE AND INFLAMMATORY STATUSÂ OF THE ELDERLY :Â L. KASZUBOWSKA1*, J.J. KACZOR2, L. HAK3, A. DETTLAFF-POKORA4, M. SZARYNSKA1, Z. KMIEC1 (2011)
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2011, 62, 1, 101-109
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2011, 62, 1, 101-109
In conclusion, we have demonstrated that healthy ageing of nonagenarians was associated with high activity of the NK cells that was related to the oxidative-inflammatory status.
Measurements of the serum indices of the oxidative state, levels of proinflammatory cytokines and NK cell activity may prove useful data to assess successful ageing.
Measurements of the serum indices of the oxidative state, levels of proinflammatory cytokines and NK cell activity may prove useful data to assess successful ageing.
DISCUSSION :
Ageing is accompanied by the alterations of both adaptive and innate immunity. The increase of serum levels of IL-6, TNF-a and other inflammatory mediators results in a state of a chronic low-grade inflammation.
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