免疫細胞の活性度と機能

めんえきさいぼうのかっせいたびときのう:免疫細胞の活性度と機能 : Activity and function of Immune cell

若い細胞ほど、より高い活性と高い治癒能力を持っている。

immune-activity

[Illust-10. 老化に伴う免疫細胞の活性度の変化]

日本の内藤メディカルクリニックに高齢化などの免疫活性試験に関する参考文献として、結論は免疫細胞の活動は二十代後の経時につれて減少しているです。

他の研究で調べてみると、

Age-related effects on Immune Cells; NK, NKT, mast cells and eosinophils

Cell type	Change with advanced age	Change
NK cells	numbers in circulation	↑ increase
	activity	↓ decrease
	cytotoxicity	↓ decrease
	Intact ADCC
	proliferation and IFN-γ production in response to IL-2	↓ decrease
NKT cells	numbers in lymphoid organs and blood	↑ increase
	Contribute to age-associated:
	in vitro T cell proliferation	↓ decrease
	in vivo DTH	↓ decrease
	IL-10 and IL-4	↑ increase
	cytotoxicity	↓ decrease
Mast cells	numbers in the skin of humans	↓ decrease
	numbers in the skin of BALB/c mice; no change in C57BL/6 mice	↑ increase
	degranulation in varicose disease	↑ increase
Eosinophils	cell number in sputum	No change
	release of EDN in response to IL-5 in asthma patients	↓ decrease
	release of EDN in response to fMLP	↓ decrease
	production of O2- in response to PMA	↓ decrease
	adhesion or chemotaxis in asthma patients	No change

略語(りゃくご):
NK: natural killer;
NKT: natural killer T
ADCC: antibody-dependent cell mediated cytotoxicity;
IFN: interferon;
IL: interleukin;
DTH: delayed-type hypersensitivity;
EDN: eosinophil-derived neurotoxin;
fMLP: formyl-methionyl-leucyl-phenylalanine;
O2- : superoxide;
PMA: phorbol myristate acetate.

Source:

Innate immunity and aging, 2009
Mariani et al., 2001; Ogata et al., 1997; Solana and Mariani, 2000; Albright and Albright, 1983; Mysliwska et al., 1992a; Mysliwska et al., 1992b; Fernandes and Gupta, 1981; Borrego et al., 1999; Dubey et al., 2000; Faunce et al., 2005;Ishimoto et al.,2004; Poynter et al., 1997; Faunce et al., 2005; Poynter et al., 1997; Mocchegiani et al., 2004; Tsukahara et al., 1997; Montagna and Carlisle, 1990; Hart et al., 1999; Nguyen et al., 2005; Pascual et al., 2007; Vignola et al., 2003
Mathur et al., 2008

そこで、一部の専門家は言う将来の技術と希望のストレージ自家幹細胞に若い必要があること。

All Stem Cells Japan