ํ™œ์„ฑ๋„์™€ ๊ธฐ๋Šฅ

๋ฉด์—ญ์„ธํฌ ํ™œ์„ฑ๋„์™€ ๊ธฐ๋Šฅ ๋ณ€ํ™”

๋…ธํ™”์— ๋”ฐ๋ฅธ ๋ฉด์—ญ์„ธํฌ ํ™œ์„ฑ๋„์˜ ๋ณ€ํ™”์— ๊ด€ํ•œ ์—ฐ๊ตฌ
์•„๋ž˜ ๊ทธ๋ž˜ํ”„๋ฅผ ๋ณด๋ฉด ์–ด๋ฆฐ ์„ธํฌ์ผ ์ˆ˜๋ก, ๋” ๋†’์€ ์„ธํฌ ํ™œ์„ฑ๋„์™€ ๊ธฐ๋Šฅ์„ ๋ณด์ž…๋‹ˆ๋‹ค.

immune-activity
[Illust-10.ย Activity of Immune cell as Ageing, Source : Naito Medical Clinic in Japan]

๋‚˜์ด๊ฐ€ ์ Š๋‹ค๊ณ  ๋ฉด์—ญ๊ธฐ๋Šฅ์„ ํ•˜๋Š” ์„ธํฌ์˜ ์ˆ˜๊ฐ€ ์ ˆ๋Œ€์ ์œผ๋กœ ๋งŽ์€ ๊ฒƒ์€ ์•„๋‹™๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์กฐ์‚ฌ์— ๋”ฐ๋ฅด๋ฉด, ๋‚˜์ด๊ฐ€ ๋“ค์—ˆ์„ ๋•Œ, ํ™œ์„ฑ๋„ ๋ฐ ๊ธฐ๋Šฅ์ด ๋–จ์–ด์ ธ ์ž์—ฐ๋ฉด์—ญ๊ธฐ๋Šฅ์— ์˜ํ•ด ๊ทธ ์ˆซ์ž๊ฐ€ ๋Š˜์–ด๋‚˜๊ธฐ๋„ ํ•˜๋ฉฐ, ๊ฐœ์ธ์ฐจ๊ฐ€ ํฌ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ๋ฉด์—ญํ™œ์„ฑ๋„ ๋ฐ ๊ทธ ๊ธฐ๋Šฅ์€ 20๋Œ€๊ฐ€ ์ง€๋‚˜๋ฉด์„œ ๋ˆˆ์— ๋„๊ฒŒ ๋–จ์–ด์ง€๋Š” ๊ฒƒ์„ ๋ณผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
๊ทธ๋ž˜์„œ ์—ฐ๊ตฌ๊ธฐ๊ด€ ๋ฐ ์ „๋ฌธ๊ฐ€๋“ค์€ ๋ฏธ๋ž˜๊ธฐ์ˆ ์— ๋Œ€๋น„ํ•ด ์ Š์€ ์„ธํฌ๋ฅผ ๋ณด๊ด€ํ•˜๋Š” ๊ฒƒ๋„ ํ•„์š”ํ•  ์ˆ˜ ์žˆ๋‹ค๊ณ  ๋งํ•ฉ๋‹ˆ๋‹ค.

๋ฉด์—ญ๊ธฐ๋Šฅ ์„ธํฌ๋“ค์˜ ๋…ธํ™”์— ๋”ฐ๋ฅธ ๋ณ€ํ™”

Cell type Change with advanced age Change
NK cells numbers in circulation โ†‘ increase
activity โ†“ decrease
cytotoxicity โ†“ decrease
Intact ADCC
proliferation and IFN-ฮณ production in response to IL-2 โ†“ decrease
NKT cells numbers in lymphoid organs and blood โ†‘ increase
Contribute to age-associated:
in vitro T cell proliferation โ†“ decrease
in vivo DTH โ†“ decrease
IL-10 and IL-4 โ†‘ increase
cytotoxicity โ†“ decrease
Mast cells numbers in the skin of humans โ†“ decrease
numbers in the skin of BALB/c mice; no change in C57BL/6 mice โ†‘ increase
degranulation in varicose disease โ†‘ increase
Eosinophils cell number in sputum No change
release of EDN in response to IL-5 in asthma patients โ†“ decrease
release of EDN in response to fMLP โ†“ decrease
production of O2- in response to PMA โ†“ decrease
adhesion or chemotaxis in asthma patients No change

ย Abbreviations:ย 
NK: natural killer
NKT: natural killer T
ADCC: antibody-dependent cell mediated cytotoxicity
IFN: interferon
IL: interleukin
DTH: delayed-type hypersensitivity
EDN: eosinophil-derived neurotoxin
fMLP: formyl-methionyl-leucyl-phenylalanine
O2- : superoxide
PMA: phorbol myristate acetate

์ž์—ฐ๋ฉด์—ญ๊ณผ ๋…ธํ™”์— ๋Œ€ํ•œ ์—ฐ๊ตฌ (Innate immunity and aging, 2009)์˜ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด,
๋ฉด์—ญ๊ธฐ๋Šฅ์„ ํ•˜๋Š” ๊ฐ ๋ฉด์—ญ์„ธํฌ๋“ค์˜ ๊ธฐ๋Šฅ์ด ๋…ธํ™”์— ๋”ฐ๋ผ ๋‹ฌ๋ผ์ง์ด ๋ณด๊ณ  ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.
๊ทธ์ค‘ ์•ž์„œ ์‚ดํŽด ๋ณธ ๊ฒƒ๊ณผ ๊ฐ™์ด NK์„ธํฌ์˜ ํ™œ์„ฑ๋„๋Š” ๋ฌผ๋ก  ์‚ฌ์ดํ† ํ†ก์‹ , ์ธํ„ฐํŽ˜๋ก ๋“ฑ NKT์„ธํฌ์˜ ๊ธฐ๋Šฅ์— ์˜ํ–ฅ์„ ์„ธํฌ๋“ค์˜ ๊ทธ ์ˆ˜๋‚˜ ๊ธฐ๋Šฅ๋„ ๋–จ์–ด์ง์„ ๋ณผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ์งˆ๋ณ‘๋ฐœ์ƒ์— ์˜ํ–ฅ์„ ์ฃผ๋Š” ๊ธฐ๋Šฅ์€ ๋Š˜์–ด๋‚˜๋Š” ๋“ฑ ์šฐ๋ฆฌ๊ฐ€ ์—ฐ๋ น์ด ๋“ค๋ฉด์„œ ๋ชธ์œผ๋กœ ๋Š๋ผ๋Š” ๋ณ€ํ™”๋ฅผ ์„ธํฌ์˜ ๊ฐ ๊ธฐ๋Šฅ๋“ค์—์„œ๋„ ๋ณผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
์—ฐ๊ตฌ์— ๊ด€๋ จ๋œ ๋ณด๋‹ค ์ž์„ธํ•œ ์‚ฌํ•ญ์„ ๋ณด๋ ค๋ฉด ALLSTEMCELLS.com์˜ ์˜์–ดํ™ˆํŽ˜์ด์ง€์—์„œ ํ™•์ธํ•ด ์ฃผ์‹ญ์‹œ์˜ค.