๋จ๋ ์ ๋ ์ฐจ์ด์ ๋ํ ์ฐ๊ตฌ
— 2015-04-27๋จ์์ ์ฌ์์ ๋ ์ฐ๊ตฌ : ๋จ์์ ๋์ ์ฌ์์ ๋๊ฐ ๊ทผ๋ณธ์ ์ผ๋ก ๋ค๋ฅผ๊น? ์ต๊ทผ BBC ์ฑ๋์์ ๋จ์ฑ๊ณผ ์ฌ์ฑ์ ๋์ ์ฐจ์ด์ ๋ํ ์ฐ๊ตฌ๋ฅผ…
[Illust-10.ย Activity of Immune cell as Ageing, Source : Naito Medical Clinic in Japan]
Cell type | Change with advanced age | Change |
---|---|---|
NK cells | numbers in circulation | โ increase |
activity | โ decrease | |
cytotoxicity | โ decrease | |
Intact ADCC | ||
proliferation and IFN-ฮณ production in response to IL-2 | โ decrease | |
NKT cells | numbers in lymphoid organs and blood | โ increase |
Contribute to age-associated: | ||
in vitro T cell proliferation | โ decrease | |
in vivo DTH | โ decrease | |
IL-10 and IL-4 | โ increase | |
cytotoxicity | โ decrease | |
Mast cells | numbers in the skin of humans | โ decrease |
numbers in the skin of BALB/c mice; no change in C57BL/6 mice | โ increase | |
degranulation in varicose disease | โ increase | |
Eosinophils | cell number in sputum | No change |
release of EDN in response to IL-5 in asthma patients | โ decrease | |
release of EDN in response to fMLP | โ decrease | |
production of O2- in response to PMA | โ decrease | |
adhesion or chemotaxis in asthma patients | No change |
ย Abbreviations:ย
NK: natural killer
NKT: natural killer T
ADCC: antibody-dependent cell mediated cytotoxicity
IFN: interferon
IL: interleukin
DTH: delayed-type hypersensitivity
EDN: eosinophil-derived neurotoxin
fMLP: formyl-methionyl-leucyl-phenylalanine
O2- : superoxide
PMA: phorbol myristate acetate