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์ง€๋ฐฉ์ค„๊ธฐ์„ธํฌ

์ง€๋ฐฉ์œ ๋ž˜์ค„๊ธฐ์„ธํฌ(Adipose derived Stem Cell)์˜ ํŠน์ง•

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์ง€๋ฐฉ์œ ๋ž˜์ค„๊ธฐ์„ธํฌ(์ง€๋ฐฉ์ค„๊ธฐ์„ธํฌ ๋˜๋Š” ์•ฝ์ž๋กœ ADSC, ASC๋ผ๊ณ ๋„ ํ•œ๋‹ค.)
์ง€๋ฐฉ์œ ๋ž˜์ค„๊ธฐ์„ธํฌ๋Š” ์ง€๋ฐฉํก์ž…์„ ํ†ตํ•ด ์‰ฝ๊ฒŒ ์–ป์„ ์ˆ˜ ์žˆ๋‹ค. ์ ์€ ์ง€๋ฐฉ์กฐ์ง์—์„œ ๋งŽ์€ ์–‘์˜ ์ค„๊ธฐ์„ธํฌ๋ฅผ ์–ป์„ ์ˆ˜ ์žˆ์œผ๋ฉฐ ์žฌ์ƒ์˜ํ•™์— ์žˆ์–ด ์œ ์šฉํ•œ ์„ธํฌ์ด๋‹ค. ๊ทธ๋ฆฌ๊ณ  ์ ์€ ์–‘์˜ ์กฐ์ง ์ฑ„์ทจ๋กœ ๋งŽ์€ ์–‘์˜ ์„ธํฌ๋ฅผ ์–ป์–ด, ๋ฐฐ์–‘ํ•˜์—ฌ ๋ฐ˜๋ณต์ ์œผ๋กœ ์ด์šฉ์ด ๊ฐ€๋Šฅํ•œ ํŠน์ง•์ด ์žˆ๋‹ค.

 

1. WHO โ€ข ์„ฑ์ธ
2. WHAT โ€ข ์—‰๋ฉ์ด, ํ—ˆ๋ฒ…์ง€, ๋ณต๋ถ€์—์„œ ์ง€๋ฐฉ ํก์ž…
3. WHEN โ€ข ๊ฑด๊ฐ•ํ•  ๋•Œ, ๋˜๋Š” ์žฌ์ƒ์„ฑ์งˆํ™˜, ์„ฑํ˜•์™ธ๊ณผ ์ˆ˜์ˆ ์ด ํ•„์š”ํ•  ๋•Œ
4. WHERE โ€ข ์ฑ„์ทจ – ์„ฑํ˜•์™ธ๊ณผ์—์„œ ๋งˆ์ทจ ํ›„ ์ฑ„์ทจ
โ€ข ๋ณด๊ด€ – ๋ณ‘์›, ๊ธฐ์—…, ์—ฐ๊ตฌ์†Œ ๋“ฑ
5. WHY ์„ธํฌ ์ฑ„์ทจ ๋ฐ ๋ณด๊ด€์„ ํ•˜๋Š” ์ด์œ 
โ€ข ๊ณต์—ฌ – ์—ฐ๊ตฌ์™€ ๊ธฐ์ฆ์„ ์œ„ํ•ด
โ€ข ๊ฐœ์ธ์šฉ – ์งˆ๋ณ‘์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ ์ž๊ฐ€ ๊ฑด๊ฐ•์„ ์œ„ํ•œ ๋ชฉ์ 
6. HOW โ€ข ํ”ผ๋ถ€, ๋ผˆ, ์กฐ์ง, ํ˜ˆ๊ด€ ๋“ฑ์„ ํ†ตํ•ด ์ด์‹ํ•˜๋Š” ๋ฐฉ๋ฒ• ๋“ฑ
7. ์ ์šฉ์ฆ(ํ˜„์žฌ ์ž„์ƒ์ค‘์ธ ์งˆํ™˜ ํฌํ•จ)
โ€ข ์„ฑํ˜•์™ธ๊ณผ, ํ”ผ๋ถ€์žฌ์ƒ, ์ฃผ๋ฆ„๊ฐœ์„ , ์—ฐ๊ณจ ์†์ƒ, ๊ด€์ ˆ ์—ผ์ฆ, ์š”์‹ค๊ธˆ, ๋ณ€์‹ค๊ธˆ, ์ง€๋ฐฉ์œ„์ถ•๋ณ‘, ์‹ฌ๊ทผ๊ฒฝ์ƒ‰, ๋‹น๋‡จ, ๊ฐ„์งˆํ™˜, ํ—ˆํ˜ˆ์„ฑ ๋ง์ดˆํ˜ˆ๊ด€์งˆํ™˜, ๋‹ค๋ฐœ์„ฑ ๊ฒฝํ™”์ฆ, ํฌ๋ก ์”จ๋ณ‘, ์•Œ์ธ ํ•˜์ด๋จธ ์งˆํ™˜ ๋“ฑ

 

์ง€๋ฐฉ์œ ๋ž˜์ค„๊ธฐ์„ธํฌ์˜ ๋ถ„ํ™”๋ฅผ ์œ ๋„ํ•˜๊ธฐ ์œ„ํ•œ ์‹คํ—˜์  ์š”์†Œ๋“ค์— ๋Œ€ํ•œ ์—ฐ๊ตฌ : Experimental factors to induce the differentiation of adipose tissue-derived stem cells

๋ถ„ํ™”์š”์†Œ ๋ถ„ํ™”์ข…๋ฅ˜ ์ž ์žฌ์  ์ž„์ƒ
Insulin, IBMX (3-isobutil-1-methylxanthine), dexamethasone, rosiglitazone, indomethasone Adipogenic ์žฌ๊ฑด ์ˆ˜์ˆ ๊ณผ ํ”ผ๋ถ€ ํ•„๋ง
bone morphogenetic protein, fibroblast growth factor, transforming growth factor, dexamethasone, insulin growth factor Chondrogenic ํ‡ดํ–‰์„ฑ ์งˆํ™˜์—์„œ์˜ ์žฌ์ƒ์ˆ˜์ˆ ๊ณผ ๊ด€์ ˆ ์žฌ์ƒ
1,25 dihydroxycholecalciferol b ฮฒ, glycerophosphate, ascorbic acid, bone morphogenetic protein 2, valproic acid Osteogenic ํ‡ดํ–‰์„ฑ ์งˆํ™˜, ์ข…์–‘, ํŠธ๋ผ์šฐ๋งˆ์—์„œ์˜ ๋ผˆ ์กฐ์ง ์žฌ์ƒ
? Myogenic ๋“€์ผ„๊ทผ ์œ„์ถ•๊ณผ ๊ฐ™์€ ํ‡ดํ–‰์„ฑ ์งˆํ™˜์˜ ์žฌ์ƒ
stem cell factor, interleukin-3,ย  interleukin-6 Cardiomyogenic ๊ธ‰์„ฑ์‹ฌ๊ทผ๊ฒฝ์ƒ‰ ์ดํ›„ ์‹ฌ์žฅ ๊ทผ์œก์˜ ์žฌ์ƒ
? Vascular/endothelial ์‹ ํ˜ˆ๊ด€ ํ˜•์„ฑ, ํ—ˆํ˜ˆ์„ฑ ์งˆํ™˜
valproic acid, insulin, hydrocortisone, epidermal growth factor, FGF Neurogenic ๋งŒ์„ฑ ํ‡ดํ–‰์„ฑ ์งˆํ™˜๊ณผ ์ค‘์‹ฌ๋ถ€์™€ ๋ง์ดˆ์‹ ๊ฒฝ ์‹œ์Šคํ…œ์˜ ์™ธ์ƒ
Activin-A, exedin-4, pentagastrin, hepatocyte growth factor, nicotinamide, glucose Pancreatic/endocrine ์ธ์Š๋ฆฐ ์˜์กดํ˜• ๋‹น๋‡จ๋ณ‘
hepatocyte growth factor, oncostatin, dimethyl sulphoxide Hepatic ๊ฐ„์˜ ์žฌ๊ตฌ์„ฑ
? Hematopoietic ์กฐํ˜ˆ(ํ˜ˆ์•ก์„ธํฌ)์˜ ์žฌ๊ตฌ์„ฑ

 

์ด ๋…ผ๋ฌธ์€ ์ง€๋ฐฉ์ค„๊ธฐ์„ธํฌ๊ฐ€ ๋‹ค์–‘ํ•œ ์„ธํฌ๋กœ ๋ถ„ํ™”๊ฐ€ ๊ฐ€๋Šฅํ•จ์„ ์ฆ๋ช…ํ•˜๋Š” ์—ฐ๊ตฌ ์ค‘ ํ•˜๋‚˜์ด๋ฉฐ, ์ž ์žฌ์ ์œผ๋กœ ์•ž์œผ๋กœ ์–ด๋– ํ•œ ์ž„์ƒ์ ์šฉ์ด ๊ฐ€๋Šฅํ•œ์ง€๋„ ๋ณด์—ฌ์ฃผ๊ณ  ์žˆ๋‹ค. | ์ถœ์ฒ˜ : Schรคffler & Bรผchler, 2007
์ž์„ธํžˆ๋ณด๊ธฐ
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