Activity and function of Immune cell

Activity and function of Immune cell

As younger cells, higher cell-activity and higher curative-influence.

immune-activity

[Illust-10. Activity of Immune cell as Ageing] As a references about Immunity activity test as ageing on Naito Medical Clinic in Japan,
the conclusion is immunocyte activities are decreasing as ageing after twenties.

 

In another study,

Age-related effects on Immune Cells; NK, NKT, mast cells and eosinophils

 

Cell type Change with advanced age Change
NK cells numbers in circulation ↑ increase
activity ↓ decrease
cytotoxicity ↓ decrease
Intact ADCC
proliferation and IFN-γ production in response to IL-2 ↓ decrease
NKT cells numbers in lymphoid organs and blood ↑ increase
Contribute to age-associated:
in vitro T cell proliferation ↓ decrease
in vivo DTH ↓ decrease
IL-10 and IL-4 ↑ increase
cytotoxicity ↓ decrease
Mast cells numbers in the skin of humans ↓ decrease
numbers in the skin of BALB/c mice; no change in C57BL/6 mice ↑ increase
degranulation in varicose disease ↑ increase
Eosinophils cell number in sputum No change
release of EDN in response to IL-5 in asthma patients ↓ decrease
release of EDN in response to fMLP ↓ decrease
production of O2- in response to PMA ↓ decrease
adhesion or chemotaxis in asthma patients No change

 

 Abbreviations: 
NK: natural killer;
NKT: natural killer T
ADCC: antibody-dependent cell mediated cytotoxicity;
IFN: interferon;
IL: interleukin;
DTH: delayed-type hypersensitivity;
EDN: eosinophil-derived neurotoxin;
fMLP: formyl-methionyl-leucyl-phenylalanine;
O2- : superoxide;
PMA: phorbol myristate acetate.

 

 Source: 

Innate immunity and aging, 2009
Mariani et al., 2001; Ogata et al., 1997; Solana and Mariani, 2000; Albright and Albright, 1983; Mysliwska et al., 1992a; Mysliwska et al., 1992b; Fernandes and Gupta, 1981; Borrego et al., 1999; Dubey et al., 2000; Faunce et al., 2005;Ishimoto et al.,2004; Poynter et al., 1997; Faunce et al., 2005; Poynter et al., 1997; Mocchegiani et al., 2004; Tsukahara et al., 1997; Montagna and Carlisle, 1990; Hart et al., 1999; Nguyen et al., 2005; Pascual et al., 2007; Vignola et al., 2003
Mathur et al., 2008

So, some experts tell that the young need to storage autologous stem cells for future technology and hope.