Activity and function of Immune cell

Activity and function of Immune cell

As younger cells, higher cell-activity and higher curative-influence.


[Illust-10.혻Activity of Immune cell as Ageing] As a references about혻Immunity activity test as ageing on혻Naito Medical Clinic in Japan,
the conclusion혻is immunocyte activities are decreasing as ageing after twenties.


In another study,

Age-related effects on Immune Cells; NK, NKT, mast cells and eosinophils


Cell type Change with advanced age Change
NK cells numbers in circulation 넁 increase
activity 넃 decrease
cytotoxicity 넃 decrease
Intact ADCC
proliferation and IFN-款 production in response to IL-2 넃 decrease
NKT cells numbers in lymphoid organs and blood 넁 increase
Contribute to age-associated:
in vitro T cell proliferation 넃 decrease
in vivo DTH 넃 decrease
IL-10 and IL-4 넁 increase
cytotoxicity 넃 decrease
Mast cells numbers in the skin of humans 넃 decrease
numbers in the skin of BALB/c mice; no change in C57BL/6 mice 넁 increase
degranulation in varicose disease 넁 increase
Eosinophils cell number in sputum No change
release of EDN in response to IL-5 in asthma patients 넃 decrease
release of EDN in response to fMLP 넃 decrease
production of O2- in response to PMA 넃 decrease
adhesion or chemotaxis in asthma patients No change


NK: natural killer;
NKT: natural killer T
ADCC: antibody-dependent cell mediated cytotoxicity;
IFN: interferon;
IL: interleukin;
DTH: delayed-type hypersensitivity;
EDN: eosinophil-derived neurotoxin;
fMLP: formyl-methionyl-leucyl-phenylalanine;
O2- : superoxide;
PMA: phorbol myristate acetate.



Innate immunity and aging, 2009
Mariani et al., 2001;혻Ogata et al., 1997;혻Solana and Mariani, 2000;혻Albright and Albright, 1983;혻Mysliwska et al., 1992a;혻Mysliwska et al., 1992b;혻Fernandes and Gupta, 1981;혻Borrego et al., 1999; Dubey et al., 2000; Faunce et al., 2005;Ishimoto et al.,2004; Poynter et al., 1997; Faunce et al., 2005; Poynter et al., 1997; Mocchegiani et al., 2004; Tsukahara et al., 1997; Montagna and Carlisle, 1990; Hart et al., 1999; Nguyen et al., 2005; Pascual et al., 2007; Vignola et al., 2003
Mathur et al., 2008

So, some experts tell that the young need to storage autologous stem cells for future technology and hope.