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Activity and function of Immune cell
Activity and function of Immune cell
As younger cells, higher cell-activity and higher curative-influence.
the conclusion is immunocyte activities are decreasing as ageing after twenties.
In another study,
Age-related effects on Immune Cells; NK, NKT, mast cells and eosinophils
| Cell type | Change with advanced age | Change |
|---|---|---|
| NK cells | numbers in circulation | ↑ increase |
| activity | ↓ decrease | |
| cytotoxicity | ↓ decrease | |
| Intact ADCC | ||
| proliferation and IFN-γ production in response to IL-2 | ↓ decrease | |
| NKT cells | numbers in lymphoid organs and blood | ↑ increase |
| Contribute to age-associated: | ||
| in vitro T cell proliferation | ↓ decrease | |
| in vivo DTH | ↓ decrease | |
| IL-10 and IL-4 | ↑ increase | |
| cytotoxicity | ↓ decrease | |
| Mast cells | numbers in the skin of humans | ↓ decrease |
| numbers in the skin of BALB/c mice; no change in C57BL/6 mice | ↑ increase | |
| degranulation in varicose disease | ↑ increase | |
| Eosinophils | cell number in sputum | No change |
| release of EDN in response to IL-5 in asthma patients | ↓ decrease | |
| release of EDN in response to fMLP | ↓ decrease | |
| production of O2- in response to PMA | ↓ decrease | |
| adhesion or chemotaxis in asthma patients | No change | |
 Abbreviations:Â
NK: natural killer;
NKT: natural killer T
ADCC: antibody-dependent cell mediated cytotoxicity;
IFN: interferon;
IL: interleukin;
DTH: delayed-type hypersensitivity;
EDN: eosinophil-derived neurotoxin;
fMLP: formyl-methionyl-leucyl-phenylalanine;
O2- : superoxide;
PMA: phorbol myristate acetate.
 Source:Â
Innate immunity and aging, 2009
Mariani et al., 2001;Â Ogata et al., 1997;Â Solana and Mariani, 2000;Â Albright and Albright, 1983;Â Mysliwska et al., 1992a;Â Mysliwska et al., 1992b;Â Fernandes and Gupta, 1981;Â Borrego et al., 1999; Dubey et al., 2000; Faunce et al., 2005;Ishimoto et al.,2004; Poynter et al., 1997; Faunce et al., 2005; Poynter et al., 1997; Mocchegiani et al., 2004; Tsukahara et al., 1997; Montagna and Carlisle, 1990; Hart et al., 1999; Nguyen et al., 2005; Pascual et al., 2007; Vignola et al., 2003
Mathur et al., 2008
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