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Adipose derived Stem Cell

Characteristic of Adipose derived Stem Cells

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Adipose derived Stem Cells are called fat stem cells or ADSCs or ASCs.

Adipose derived Stem Cells(ADSCs) can be simply collected with liposuction.
A large amount of stem cells in small adipose tissue can be a useful ideal in regenerative medicine.
And large amounts of stem cells from small fat tissue can be obtained and those can be derived easily multiple times.
1. WHO • Adult
2. WHAT • Liposuction the fat from hip, thigh, abdominal region
3. WHEN • Always in good health or biopsy for patient’s disease diagnosis.
4. WHERE • Collect – Plastic surgery
• Storage – Companies, hospitals, laboratories
5. WHY The reason to collect and storage
• for public – research
• for private – self health against diseases
6. HOW • Plantation to skin, vessels, bones after cultivation or non-cultivation
7. Application (included diseases under investigation)
• Multipotency of adipose derived stem cells can apply to various diseases.
Plastic surgery, Cosmetic surgery(CAL: Cell Assisted Lipotransfer), Wrinkle care, Cartilage damage, Joint inflammation, Urinary incontinence, Scatacratia, Lipoatrophy, Myocardial infarction, diabetes liver disease, ischemic peripheral vascular disease, multiple sclerosis, Perianal hematoma, Alzheimer’s disease, etc.

Experimental factors to induce the differentiation of adipose tissue-derived stem cells

Differentiation factors Type of differentiation Clinical potential
Insulin, IBMX (3-isobutil-1-methylxanthine), dexamethasone, rosiglitazone, indomethasone Adipogenic Reconstructive surgeries, skin filling
bone morphogenetic protein, fibroblast growth factor, transforming growth factor, dexamethasone, insulin growth factor Chondrogenic Reconstructive surgeries, joint repair in degenerative diseases
1,25 dihydroxycholecalciferol b β, glycerophosphate, ascorbic acid, bone morphogenetic protein 2, valproic acid Osteogenic Bone tissue regeneration in degenerative diseases, tumors and traumas
? Myogenic Regeneration in degenerative diseases such as Duchenne muscular dystrophy
stem cell factor, interleukin-3,  interleukin-6 Cardiomyogenic Regeneration of cardiac muscle after acute myocardial infarction
? Vascular / endothelial Neovascularization / ischemic diseases
valproic acid, insulin, hydrocortisone, epidermal growth factor, FGF Neurogenic Chronic-degenerative diseases and central and peripheral nervous system traumas
Activin-A, exedin-4, pentagastrin, hepatocyte growth factor, nicotinamide, glucose Pancreatic/endocrine Diabetes mellitus type 1
hepatocyte growth factor, oncostatin, dimethyl sulphoxide Hepatic Hepatic regeneration
? Hematopoietic Hematopoetic reconstitution
Source: Schäffler & Büchler, 2007
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