Adipose derived Stem Cell
Characteristic of Adipose derived Stem Cells
![msc_01](http://www.allstemcells.com/wp-content/uploads/2015/05/msc_01.jpg)
Adipose derived Stem Cells are called fat stem cells or ADSCs or ASCs.
Adipose derived Stem Cells(ADSCs) can be simply collected with liposuction.
A large amount of stem cells in small adipose tissue can be a useful ideal in regenerative medicine.
And large amounts of stem cells from small fat tissue can be obtained and those can be derived easily multiple times.
1. WHO |
• Adult |
2. WHAT |
• Liposuction the fat from hip, thigh, abdominal region |
3. WHEN |
• Always in good health or biopsy for patient’s disease diagnosis. |
4. WHERE |
• Collect – Plastic surgery
• Storage – Companies, hospitals, laboratories |
5. WHY |
The reason to collect and storage
• for public – research
• for private – self health against diseases |
6. HOW |
• Plantation to skin, vessels, bones after cultivation or non-cultivation |
7. Application (included diseases under investigation) |
• Multipotency of adipose derived stem cells can apply to various diseases.
Plastic surgery, Cosmetic surgery(CAL: Cell Assisted Lipotransfer), Wrinkle care, Cartilage damage, Joint inflammation, Urinary incontinence, Scatacratia, Lipoatrophy, Myocardial infarction, diabetes liver disease, ischemic peripheral vascular disease, multiple sclerosis, Perianal hematoma, Alzheimer’s disease, etc. |
Experimental factors to induce the differentiation of adipose tissue-derived stem cells
Differentiation factors |
Type of differentiation |
Clinical potential |
Insulin, IBMX (3-isobutil-1-methylxanthine), dexamethasone, rosiglitazone, indomethasone |
Adipogenic |
Reconstructive surgeries, skin filling |
bone morphogenetic protein, fibroblast growth factor, transforming growth factor, dexamethasone, insulin growth factor |
Chondrogenic |
Reconstructive surgeries, joint repair in degenerative diseases |
1,25 dihydroxycholecalciferol b β, glycerophosphate, ascorbic acid, bone morphogenetic protein 2, valproic acid |
Osteogenic |
Bone tissue regeneration in degenerative diseases, tumors and traumas |
? |
Myogenic |
Regeneration in degenerative diseases such as Duchenne muscular dystrophy |
stem cell factor, interleukin-3, interleukin-6 |
Cardiomyogenic |
Regeneration of cardiac muscle after acute myocardial infarction |
? |
Vascular / endothelial |
Neovascularization / ischemic diseases |
valproic acid, insulin, hydrocortisone, epidermal growth factor, FGF |
Neurogenic |
Chronic-degenerative diseases and central and peripheral nervous system traumas |
Activin-A, exedin-4, pentagastrin, hepatocyte growth factor, nicotinamide, glucose |
Pancreatic/endocrine |
Diabetes mellitus type 1 |
hepatocyte growth factor, oncostatin, dimethyl sulphoxide |
Hepatic |
Hepatic regeneration |
? |
Hematopoietic |
Hematopoetic reconstitution |
Source: Schäffler & Büchler, 2007
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