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Purging old cells extends lifespan

Author
Master
Date
2016-03-09 07:44
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61568

IT셎 an extreme take on detox.
Clearing out old cells helps mice live longer, and seems to stave off a multitude of age-related diseases.
When cells wear out, they don셳 always die. Sometimes they hang around, pumping out damaging compounds. Get rid of these cells and a host of benefits ensue, suggest mouse studies by Darren Baker and his colleagues at the Mayo Clinic in Rochester, Minnesota.
By tagging the cells with a 쐓uicide gene, the team were able to wipe them out in the animals.
The treated mice lived around 25 per cent longer than untreated mice, on average. 쏷hat셲 the equivalent of extending human life from 80 to 100 years, says Baker. What셲 more, the mice were less ravaged by age.
After six months of twice-weekly treatment, their hearts were healthier and they were better at recovering from stress. Their kidneys had less age-related scarring, and they didn셳 develop cataracts or cancer until later in life, compared with untreated mice. They even looked younger, because they didn셳 show the same fat loss as untreated mice (Nature, doi.org/bcb2).
The race is now on to find drugs that clear these cells in people. 쏛 few years ago, I would have said we were a long way off, says Baker. 쏝ut we셶e been working with a company and it셲 easier than we thought.

Source : New Scientist, February 2016



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