SENSITIVITY OF NATURAL KILLER CELLS TO ACTIVATION IN THE PROCESS OF AGEING

This report show the correlation of Natural Killer Cells Activity and aging.

Source :혻SENSITIVITY OF NATURAL KILLER CELLS TO ACTIVATION IN THE PROCESS혻OF AGEING IS RELATED TO THE OXIDATIVE AND INFLAMMATORY STATUS혻OF THE ELDERLY :혻L. KASZUBOWSKA1*, J.J. KACZOR2, L. HAK3, A. DETTLAFF-POKORA4, M. SZARYNSKA1, Z. KMIEC1 (2011)
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2011, 62, 1, 101-109

www.jpp.krakow.pl

In conclusion, we have demonstrated that healthy ageing of nonagenarians was associated with high activity of the NK cells that was related to the oxidative-inflammatory status.
Measurements of the serum indices of the oxidative state, levels of proinflammatory cytokines and NK cell activity may prove useful data to assess successful ageing.

DISCUSSION :

Ageing is accompanied by the alterations of both adaptive and innate immunity. The increase of serum levels of IL-6, TNF-a and other inflammatory mediators results in a state of a chronic low-grade inflammation.

 



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